Selleck made a number of cameos during the popular comedy's ten-year run, earning an Emmy Award nomination for his final appearance as Monica's ex-boyfriend in season six finale The One with the Proposal.
Speaking to Radio Times, the actor said that he would "absolutely" return should a much-talked about movie ever get the go-ahead.
"I'd say yes without even seeing a script," Selleck said. "What would be really good is for Richard to come between Monica and Chandler again.
"I'd hope there'd still be sparks. I loved that scene as the eye doctor looking into her eyes. Courteney Cox has very pretty eyes."
"I know Matthew's father John Bennett Perry very well. We used to be in competition as young actors and he'd always get the parts I wanted."
The full interview with Selleck appears in the new issue of Radio Times, out now.
E4 recently finished broadcasting repeats of Friends in the UK.
> Courteney Cox: 'Friends movie won't happen'