The series, which will premiere on NBC tonight, stars stand-up comedian Whitney Cummings and has a multi-camera format.
Thomas has now told TV Guide that people are "closed off" to shows filmed that way.
"I think there are a lot of people that enjoy smart comedy that feel that multi-cam is an old-fashioned lesser form - it's for broader, cheaper humour," she said. "I think it's developed a reputation that isn't really fair. So I think we're hoping that people will just be open-minded to our show and embrace what we're doing regardless of its format."
Thomas admitted that the team is feeling "a little pressure" about being part of NBC's Thursday night comedy lineup, but also appeared to criticise the other shows.
"There's a comedy snobbery around the Thursday night lineup folks that I find incredibly irritating," she said. "It's like somehow it became cool to stop trying to be funny. I think the single-cam, like smirking at the camera, mockumentary thing is one way to do comedy, but I don't think it's the only way."
Thomas argued that "the most successful comedies in television are multi-camera" and explained that she wants Whitney to "relate to people's lives in a way that isn't really on television right now".
"We're just making comedy, that's all we're doing," she continued. "We're not trying to prove a huge point, we're just trying to entertain people for 30 minutes as they wind down their day as they get their kids to bed. It's not rocket science, you know. Everybody just needs to relax a little bit about it. Everybody just stop taking yourself so f**king seriously."
Thomas added: "For all kinds of reasons, I think people are rooting for our demise. I think that you've got to brush that off and go, 'Well, people hopefully will show up and tune in and be open-minded and enjoy it'."
Cummings has previously claimed that the multi-camera format is the best for stand-up comedians and defended the decision to film in front of a live audience.
Whitney will premiere tonight at 9.30/8.30c on NBC.