The actor will play Dr Cameron Fischer in the fifth episode of the show's sophomore season, The Hollywood Reporter says.
Cameron is an anatomy professor but becomes guarded when one of his cadavers disappears during class, causing Megan (Dana Delany) to investigate.
Harrison has recently played Julian's father in One Tree Hill and has previously worked on shows including Reunion, Joey, Judging Amy and Ed.
Other stars who have landed appearances in the new season of Body of Proof include Deirdre Lovejoy, Chrishell Stause and Nathalie Kelley.
The show continues on Tuesdays at 10/9c on ABC.