Cox, who starred in NBC's hit series Friends for a decade, is exec producing the show with her ex-partner David Arquette.
Titled Ten Years, it will chart the lives and relationships of a group of friends across a decade.
The programme will be written by Howard J Morris (According To Jim), reports Deadline.
Cox's comedy is one of two projects sold to NBC by ABC Studios.
Daniel Taplitz, Ian Sanders and Kim Moses's The Next Insanely Great Thing is the other series in the early development stages. It is a comedy based around a suburban town, which is used as a guinea pig for a technology company's social media experiments.
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