Blade Anime begins next year and Marvel's head of TV Jeph Loeb announced that The Matrix franchise star has landed the lead role.
"It's very exciting and a very cool job," Perrineau said at New York Comic-Con this weekend. "I get to wield a sword and kill vampires and just generally be a badass."
Last year, Marvel Entertainment announced a new partnership with Japanese animation studio Madhouse to produce several anime series based on its most popular characters.
Wesley Snipes, who portrayed Blade in all three theatrical films, said that he is still 'first in line' for the role if the franchise continues for another instalment.
Blade Anime launches on G4 in January 2012.