Winfrey ended her award-winning daytime talkshow earlier this year after more than 25 years on air.
DeGeneres commented that many of Winfrey's fans would very likely enjoy her own chatshow.
"I think we'll get a new audience that maybe didn't watch me because they only watched Oprah, and they have a void now," she told Parade.
DeGeneres went on to insist that she is unwilling to betray her own vision for The Ellen DeGeneres Show in order to attract new viewers.
"[I have] the same goal whether we have 10 people or 10 million people watching," she said. "If we adjust in any way, it's so we can top ourselves."
DeGeneres recently revealed that she and wife Portia de Rossi do not want to have children.
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