The veteran presenter will exit the series on November 18, with his final featuring "some of Philbin's favourite guests and friends", including Donald Trump, Don Rickles and Jimmy Fallon.
Each day will also see special musical guests performing a tribute to Philbin, including Tony Bennett, Bret Michaels and Josh Groban.
The final show will be an hour-long tribute episode dedicated to his 28 years presenting Live!.
Regis Philbin recently said that he doesn't know what he'll do once he leaves the series.
Jerry Seinfeld will present three episodes of Live! with Kelly Ripa in the days following Philbin's exit.