The rap star - real name Curtis Jackson - will play a hip-hop mogul on the Bones spinoff, according to TV Line.
His character Big Glade will hire Walter (Geoff Stults) to track down the lost tracks of a deceased rap artist on his label.
The episode will be directed by Bones star David Boreanaz and is expected to air in February 2012.
50 Cent has previously acted in such films as 2008's Righteous Kill and 2009's Dead Man Running, as well as 2005's semi-autobiographical Get Rich or Die Tryin'.
Mercedes Masöhn and Maddie Hasson joined The Finder in July, to replace departing cast member Saffron Burrows.
Bones star John Francis Daley (Sweets) will also make a crossover appearance in the new drama.
The Finder will premiere on Fox in January.
> 50 Cent to play pimp in serial killer movie The Frozen Ground
Watch a trailer for The Finder below: