Comedy Central revealed that the Trey Parker and Matt Stone animated comedy, which it renewed in June, will be given a three-season extension to reach a milestone 20th run.
Michele Ganeless, president of the cable network, said in a statement: "The collective genius of Matt and Trey knows no bounds.
"Week after week and season after season they continue to surprise and delight South Park fans, and that includes all of us here at Comedy Central.
"We're thrilled that the adventures of Stan, Kyle, Kenny and Cartman will continue through 2016."
Creators Stone and Parker have been running the Emmy-winning show since 1997.
South Park's 15th season concludes tonight (Wednesday) in the US at 10pm on Comedy Central.
> South Park not over, says creators Trey Parker, Matt Stone