The actor will appear in the CBS drama next year, Entertainment Weekly reports.
His character Curtis, who is described as likeable and well-off, is accused of murder by his stepdaughter when his second wife dies.
However, the stepdaughter is said to be "neurotic" and claims that God told her Curtis was responsible.
Busfield has previously starred in shows including thirtysomething, The West Wing and Studio 60 on the Sunset Strip. He recently had a guest role in Law & Order: SVU.
Blue Bloods airs on Fridays at 10/9c on CBS.
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