The former Seinfeld star is guest-hosting Live! in the wake of Regis Philbin's departure.
During an interview with Kim Cattrall, who plays Samantha, Seinfeld compared the nymphomaniac to the character played by Michael Richards on his own sitcom.
"I always felt like there was a certain similarity - and I mean this in a good way - Sarah Jessica (Parker, star of Sex and the City) and I were kind of like the hub of the wheel, and then you had these other eccentric characters, and you were kind of the Kramer of the show," Seinfeld told Cattrall.
"Yes! I'll take it! I love him," she answered.
Cattrall recently admitted that she feels limited in the types of roles she is presented thanks to the years she spent playing Samantha.