Life's Too Short - starring dwarf actor Warwick Davis, Gervais and Stephen Merchant as fictional versions of themselves - will premiere on February 19 at 10.30pm.
The series also sees appearances from the likes of Johnny Depp, Sting and Liam Neeson, and focuses on Davis's struggle with regaining fame and fortune.
Gervais recently responded to criticism of the series in the UK, saying that it "satirises" rather than actually exploits Davis.
The premiere will be just over a month after Gervais hosts the Golden Globes for the third time.
HBO also airs animated series The Ricky Gervais Show, which adapts the podcasts and audiobooks from Gervais, Merchant and Karl Pilkington.
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Watch a clip of Johnny Depp in Life's Too Short below: