The Chuck star has signed up to appear in an episode of the show's third season, TV Line reports.
Details of his character are currently being kept under wraps.
However, he is expected to have a storyline with Susan Lucci, who is returning to the show and will again play a heightened version of herself.
McPartlin is best known for his role as Awesome in Chuck, which is currently airing its final season on Fridays at 8/7c on NBC.
He also recently signed up to appear in an episode of Fox's new comedy I Hate My Teenage Daughter.
The third season of Hot In Cleveland airs on Wednesdays at 10/9c on TV Land.