The actress will reunite with her Clueless co-star Jeremy Sisto on the ABC sitcom, according to TVLine.
Silverstone will appear in a multi-episode arc as Eden, a potential love interest for single father George (Sisto).
The character's arrival will lead to a disagreement between George and his new friend Noah (Alan Tudyk).
Silverstone is best known for her film roles, including appearances in 1997's Batman & Robin and the same year's Excess Baggage.
She starred in short-lived NBC comedy-drama Miss Match in 2003 and recently played a guest role on Adult Swim's Childrens Hospital.
Robin Givens has also landed a role in Suburgatory.
The House of Payne actress will play Tulsa, a rival of Dallas (Cheryl Hines), in a March episode.
Suburgatory airs on Wednesdays at 8.30/7.30c on ABC.
> Jersey Shore star The Situation to guest in Suburgatory
Watch a trailer for Suburgatory below: