The upcoming ABC show was originally known by the titles Good Christian Bitches and Good Christian Belles, but Harling told reporters at the Television Critics Association that it is not the series' intention to attack religion.
"The church is the centre," he said, according to Entertainment Weekly. "Church is sacred. There are rules.
"You have to be respectful of those rules and the joy of it [is] watching these people try to function within these rules. The goal is to watch these people try to be good."
Harling continued: "What we emphasise is that we will never ever look at this in any other way than the most respectful as possible. We will never, ever be disrespectful."
Harling and GCB star Leslie Bibb also dismissed comparisons between the show and ABC's Desperate Housewives.
GCB, which will feature guest appearances from the likes of Kevin Alejandro, Grant Bowler and Sheryl Crow, will premiere in March.