Tatum will guest on the NBC sketch comedy series on February 4 for the first time alongside Grammy-nominated band Bon Iver.
Deschanel makes her own first appearance on SNL the following week on February 11 with 'Crash Your Party' group Karmin.
The New Girl actress was recently spoofed by Saturday Night Live star Abby Elliott in a sketch about celebrities replacing Regis Philbin on his daytime series.
This weekend's edition of Saturday Night Live features guest host Daniel Radcliffe and music from Lana Del Rey.
Radcliffe has commented that hosting SNL was a "no-brainer", adding that he has received encouragement from his How to Succeed in Business Without Really Trying co-star John Larroquette.
Saturday Night Live airs weekends at 11.30/10.30c on NBC.
> Daniel Radcliffe SNL promo: Sex wizards and American accents - video
> Abby Elliott: 'SNL has cocaine schedule without the cocaine'
Watch Abby Elliott spoof Zooey Deschanel on Saturday Night Live below (US only):