The Keeping Up With The Kardashians star will join Kelly Ripa on the Monday, January 23 instalment of the daytime talkshow, which will feature guest Kevin McHale, who plays Artie in Glee.
Kardashian's appearance will kick off an all-female week of guest co-hosts.
She wrote on her Twitter account after the announcement was made: "So excited, Ive been wanting share this for weeks now, it was announced today, I'm co-hosting @LiveKelly 1-23-12! Can't wait 2 see @KellyRipa. (sic)"
Ripa responded: " I can't wait to see you! Xoxoxoxo."
Kardashian is the latest in a string of celebrities to act as guest co-hosts on the show as the search for a permanent replacement for Regis Philbin continues.
Jerry Seinfeld, Neil Patrick Harris, Rob Lowe, Jim Parsons and David Duchovny are among the stars who have already hosted, with Mario Lopez, Seth Meyers and Dana Carvey among those who will host next week.
> Rob Lowe 'in talks' for permanent 'Live with Kelly!' role
> Regis Philbin: 'I'm too busy to miss Live with Kelly!'