The project is set in a future world where humans and aliens are engaged in a desperate war, according to TVLine.
Former True Blood star Bowler will play the chief law-keeper of a burgeoning town who becomes caught up in the global conflict.
The actor, who also starred on Ugly Betty between 2008 and 2010, recently appeared alongside Jason Statham, Clive Owen and Robert De Niro in 2011 action film Killer Elite.
His additional television credits include episodes of Lost, The Cape and Farscape.
Syfy is currently developing a number of original projects, including a paranormal comedy pilot executive produced by Jack Black.
Adaptations of Matt Damon film The Adjustment Bureau and comic books Booster Gold and Ghost Projekt are also in the works.
The cable channel has also picked up supernatural thriller Haven for a third season, but opted to drop in-development reality series Culture Shock with Tommy Lee.
> Grant Bowler lands Atlas Shrugged role