Harry Potter star Radcliffe will join Kelly Ripa on the Tuesday, January 31 instalment of the daytime talkshow, which will feature guest Rachel McAdams.
Facinelli, who plays Dr Cullen in the Twilight franchise and Dr Cooper in Nurse Jackie, will join Ripa for a talk with Jersey Shore stars Nicole 'Snooki' Polizzi and Jenni 'JWoww' Farley on Thursday, February 2.
ABC News contributor and author Dan Abrams will be the guest host on Monday, January 30, when The Vow actor Channing Tatum will be interviewed, while America's Got Talent judge Howie Mandel will guest host the Wednesday, February 1 episode featuring American Idol's Jennifer Lopez.
Comedian DL Hughley rounds up the guest hosts of the week on Friday, February 3.
Live with Kelly! has boasted a string of celebrity guest hosts each week following the departure of Regis Philbin last year.
Kim Kardashian, Mary J Blige, Cat Deeley, Kristin Chenoweth and Carrie Ann Inaba will all serve as guest hosts on next week's all-female lineup.
> Kim Kardashian to guest co-host Live with Kelly!: I'm so excited
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