American Judy will star the actress as a cosmopolitan city girl who struggles to adapt to family life in the suburbs, according to Deadline.
Greer is currently part of the voice cast on FX animated comedy Archer and has also played recurring roles on Two and a Half Men and Californication.
Her new project has been scripted by Leap Year writers Deborah Kaplan and Harry Elfont, while David Gardner will serve as executive producer.
ABC has recently ordered a string of comedy pilots for the 2012-13 television season, including a sci-fi comedy from Crazy, Stupid, Love. writer Dan Fogelman, family sitcom How to Live With Your Parents for the Rest of Your Life and a remake of the British series White Van Man.
Scrubs producers Steven Cragg and Brian Bradley are also said to be working on an adaptation of UK sitcom Only Fools and Horses.
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