The movie is based on the 2010 book of the same name by political journalists John Heilemann and Mark Halperin, and stars Ed Harris as Republican presidential candidate John McCain and Moore as his running mate Sarah Palin.
The project from HBO Films follows what happens after Palin is picked by McCain as his running mate for his presidential campaign.
"I miss my baby," Moore says as Palin in the trailer.
Woody Harrelson also stars as McCain's adviser Steve Schmidt, who says: "She's on the verge of a complete nervous breakdown."
Game Change is directed by Jay Roach (Austin Powers, Dinner for Schmucks) and will premiere on March 10 on HBO.
> Julianne Moore: 'Sarah Palin role was really hard'
Watch the Game Change trailer below: