The project, which is currently untitled, focuses on a man who realises that his best friend is the love of his life after having a health scare.
Garcia has now signed up for the female lead in the show, Deadline reports.
The pilot comes from Friends, How I Met Your Mother and Will & Grace producer Greg Malins and Dawson's Creek, Everwood, Eli Stone and Brothers & Sisters alum Greg Berlanti.
Garcia previously worked with Malins on her recent comedy Better With You.
Her other credits include parts in Gossip Girl, Reba, Privileged and Freaks and Geeks.
Garcia had been attached to an ABC comedy project about a woman who moves in with her husband's family, but the network decided not to order a pilot.
Other pilots currently in the works at CBS include a cop drama called Golden Boy, Jerry Bruckheimer's Trooper, a show from Goodfellas writer Nicholas Pileggi and Elementary, a controversial modern-day take on the Sherlock Holmes stories.
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