The untitled project will focus on two women who have remained life-long friends, despite their different lifestyles.
Nicole (Anders) has a faithful husband and loving family, while her best friend Jen has left behind a broken marriage and resentful parents, according to Deadline.
Anders's most recent project was last year's short-lived Matthew Perry sitcom Mr. Sunshine.
She previously appeared alongside Perry's Friends co-star Matt LeBlanc in spinoff series Joey and also starred in ABC's Better Off Ted and CBS sitcom The Class.
Other comedy projects currently in development at NBC include Daddy's Girl from Friends producer Dana Klein, Roseanne Barr's Downwardly Mobile and a remake of UK sitcom Friday Night Dinner.
Glee co-creator Ryan Murphy's The New Normal, a new series from Sarah Silverman and Anne Heche vehicle Save Me are also in the works.
> Weeds star Justin Kirk joins NBC pilot Animal Kingdom