The star of TNT's The Closer will switch from drama to comedy to appear alongside Kyle Bornheimer in the half-hour pilot.
White Van Man is a remake of Will Mellor's BBC comedy about a man taking over his father's handyman business.
Bornheimer has the role played by Mellor in the original, while Simmons is cast as the father.
Simmons, who plays assistant chief Will Pope in The Closer, is available for pilot season for the first time in eight years and, according to Deadline, opted to do White Van Man after a number of other comedy offers.
ABC has other UK show remakes in the pipeline, including drama Mistresses and classic comedy Only Fools and Horses.
> Kyle Bornheimer joins ABC 'White Van Man' pilot