The actor stars in Awake as a police detective caught between two alternate realities after being involved in a car crash with his wife and son.
Speaking about the series to Collider, Isaacs suggested that he was immediately intrigued by his character's determination to figure out his true existence.
"One of the challenging and fun things about this - and you can ask the writers how much fun they have, but I think the answer would be, 'None' - is that nothing is the same. No episode is the same, as things progress," Isaacs explained.
"Although these are completely weekly, close-ended, procedural stories, it's also true that his world changes, all the time."
Isaacs added of Awake's journey of discovery: "When we first find him, in the pilot, he absolutely wants things to stay the same. With these two worlds, he doesn't know which one's real and he's fine with that. He's not stupid.
"He knows one of them must be a dream, and he must have either lost his son or his wife, and he doesn't want to engage with that loss. But that will take its toll on him, and there will be consequences."
Isaacs continued: "There's a price to pay, for that kind of denial, partly in his relationships with his wife and his son. So, he will change his attitude to it. Of course he will."
Wilmer Valderrama, Steve Harris and Cherry Jones round out the cast of Awake, which premieres Thursday, March 1 at 10/9c on NBC.
Awake's creator Howard Gordon recently promised that the Isaacs-led thriller will not be confusing for viewers.
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