The project - from The New Adventures of Old Christine's Kari Lizer - will focus on two women who have remained lifelong friends, despite their different lifestyles.
While Jen (Dratch) has left behind a broken marriage and resentful parents, her best friend Nicole (Andrea Anders) has a faithful husband and loving family.
Danny Comden will also star as Jen's wild chef ex-husband, according to TV Guide.
Dratch featured regularly on Saturday Night Live from 1999 to 2006 and has also appeared on 30 Rock, while Comden starred in 1998 horror film Urban Legend.
Lizer will write and executive produce the Lady Friends pilot, with 2 Broke Girls' Scott Ellis directing.
NBC's other comedy pilots in contention for the 2012-13 television season include Save Me starring Anne Heche, Glee co-creator Ryan Murphy's The New Normal and Next Caller Please with Cougar Town's Collette Wolfe.
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