Winfrey appeared on Jimmy Kimmel Live: After the Academy Awards on Sunday (February 26) and talk quickly turned to how the presenter can spice up OWN's programming.
Kimmel's advice included a new take on Winfrey's famous 'Book Club' with the series Oprah's Book Club Fight Club.
"Let's be honest, reading is like the most boring thing in the world, so this show takes your Book Club and gives it a twist," Kimmel said.
Kimmel then cut to a fictitious clip from the series, where Winfrey brawled with a panelist while arguing about To Kill A Mockingbird.
The late-night host also offered other programming suggestions including Oprah Repos Her Favourite Things and The Jimmy & Oprah Interview, which featured the two hosts chatting with Jennifer Aniston while both speaking at the same time.
Winfrey eventually dismissed all of Kimmel's suggestions as "off-brand".
Kimmel's Oscar special also featured George Clooney, Matt Damon, Tom Hanks and Meryl Streep in a trailer parodying Hollywood blockbusters.
Jimmy Kimmel Live airs weeknights at 12/11c on ABC.
More from the Oscars 2012:
> Oscars 2012: 'The Artist', 'Hugo' win five Academy Awards
> Oscars: 'The Artist' wins 'Best Picture' Academy Award
> Oscars: Meryl Streep pays tribute to friends in 'Best Actress' speech
> Oscars 2012: Jean Dujardin wins 'Best Actor' for 'The Artist'
> Oscars: Billy Crystal remembers Gil Cates in 'In Memoriam' segment
> Oscars: 'The Artist's Michel Hazanavicius win 'Best Director' gong
> Oscars 2012: Bret McKenzie triumphs in 'Best Original Song' category
> Christopher Plummer wins 'Best Supporting Actor' Oscar for 'Beginners'