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The Oscar-winning Descendants screenplay writer will take the male lead in the show, according to The Hollywood Reporter.
The single-camera comedy - previously titled Ben Fox Is My Manny - has been written by Dana Fox (Couples Retreat, What Happens in Vegas).
The show focuses on an uptight single mother whose laid-back brother moves in with her to help raise her child. The male lead is reportedly based on Dana Fox's real-life brother Ben.
Faxon joins Saturday Night Live star Abby Elliott, who will play the mother.
Child star Maggie Jones was also cast in the pilot earlier this month.
The 8-year-old previously appeared in Fox's 2010 project Most Likely to Succeed.
