World Without End, based on the novel by Ken Follett, focuses on a young woman called Caris who urges the residents of her medieval town Kingsbridge to save their community from forces including the Church and Crown.
Wuthering Heights star Charlotte Riley will play Caris, while other stars involved in the eight-part series include Cynthia Nixon and Miranda Richardson.
Spooks actor Peter Firth and Mad Dogs's Ben Chaplin are also featured in the drama.
Meanwhile, Labyrinth is based on a novel by Kate Mosse and intertwines stories from the present day and the Crusades, as two heroines from the different periods have to work together to stop a 4,000-year-old secret from being unveiled.
John Hurt, Harry Potter's Tom Felton and Gossip Girl star Sebastian Stan will appear in the drama alongside Downton Abbey's Jessica Brown-Findlay, Great Expectations actress Vanessa Kirby, Janet Suzman and Threesome and Game of Thrones actor Emun Elliott.
Merlin's Katie McGrath, who will also appear in Labyrinth, previously told Digital Spy that the show has a sense of "gritty realism" with "blood, guts and gore".
Channel 4's Tim Highsted said: "We are delighted to build on the success of last year's The Pillars of the Earth and to continue to work with [production company] Tandem. These epic historical dramas combine compelling storytelling, top-notch casting and excellent production values."
Both World Without End and Labyrinth will air on Channel 4 later this year.