The Happy Days star will play the grandmother of Chris (Will Arnett) when she appears in the NBC comedy, TV Line reports.
Ross's character loves her grandson but is less impressed with Reagan (Christina Applegate), who wants her to hand over an heirloom.
As well as starring in Happy Days, Ross had a part in Gilmore Girls and has had guest roles in shows such as Grey's Anatomy, Brothers & Sisters and Nurse Jackie.
Ross's casting comes after her Happy Days co-star Henry Winkler signed up last month to play the father of Ava (Maya Rudolph) in Up All Night.
Stevie Nicks and Fred Armisen are among the other stars who have landed guest roles in the comedy, which airs on Thursdays on NBC.