The Happy Feet Two actor will be presented with the prize at the second annual Comedy Awards in New York on April 28.
"Robin Williams is a comedic force of nature whose intensity and explosive free-associating style as a stand-up comedian made him a superstar," said Viacom Entertainment Group Executive Producer Casey Patterson.
"Academy Award winner, beloved TV star and passionate activist, Robin used stand-up comedy to literally change the world with Comic Relief.
"Robin Williams is more than an icon... he is one of the most important comedic voices of our time. We're thrilled, and just a little bit scared, to be honouring Robin at The Comedy Awards this year."
Last year's recipient was A Thousand Words actor Eddie Murphy, who was presented with the award by Tracy Morgan.
The Comedy Awards will air on Comedy Central in the US on Sunday, May 6.
Watch Robin Williams talk to Digital Spy about Happy Feet Two below: