Romney's chat with Jay Leno on Tuesday (March 27) will be the former Massachusetts governor's first Tonight Show appearance of the 2012 election campaign.
The candidate is currently scheduled to be the first guest interviewed on the programme.
Romney has been on a guest on The Tonight Show three times prior to his current presidential bid.
He first appeared on The Tonight Show in May 2007, prior to his first presidential run. Romney most recently sat down with Leno in 2010.
The Tonight Show with Jay Leno airs weeknights at 11.35/10.35c on NBC.
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Watch Jay Leno spoof Mitt Romney's presidential bid below: