The I Hate My Teenage Daughter actress will play prison warden Melinda in the drama, who is said to be a "sexy, ominous woman with a sadistic streak", reports Deadline.
The move will see Pressly return to NBC after she starred in My Name is Earl as Joy, a role which earned her an Emmy award.
Bad Girls is a remake of the UK's ITV drama, which ran from 1999 to 2006 and followed the inmates and officers in a women's prison.
CSI actress Tracee Ellis Ross recently signed up to appear in the drama, while Jurnee Smollett (Friday Night Lights), Zoe Boyle (Downton Abbey), Rick Gonzalez (Reaper), Amy Smart (Crank) and Karolina Wydra (House) will also star.
Shameless showrunner John Wells will executive produce the pilot alongside Andrew Stearn and Nancy Pimental, as well as a team of British producers from Shed Media.
Pressly revealed last year that she was hesitant to return to TV after My Name is Earl was cancelled.
I Hate My Teenage Daughter was itself cancelled earlier this week.