The Léon star will play an elite homicide cop in the English-language series, reports Deadline.
Each episode will revolve around an iconic location in the French capital of Paris, including Nôtre Dame, the Place de la Concorde and the Opéra.
Rene Balcer (Law & Order) created the series alongside writers Franck Ollivier and Malina Detcheva (Empire of the Wolves).
Reno is known both for his Hollywood movie credits - including roles in 1998's Ronin and 2006's The Da Vinci Code - and his work in French film, such as 1993's Les Visiteurs and its 1998 sequel.
Le Grand will mark his first regular role on series television.
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Watch the trailer for Jean Reno's 1994 film Léon below: