According to The Hollywood Reporter, Slade will also take on executive producing duties alongside Pushing Daisies creator Bryan Fuller.
Slade has directed episodes of Breaking Bad and Awake, and his pre-Twilight movie credits include 30 Days Of Night and Hard Candy.
A full 13-episode series has already been ordered for Hannibal, which will centre on Hannibal Lecter in his early days.
Hugh Dancy has been cast as FBI agent Will Graham, who is mentored by Lecter. No casting has yet been announced for the Lecter role, which has been played on the big screen by Anthony Hopkins and Brian Cox.
Watch a trailer for 2002 film Red Dragon, in which Ed Norton plays Will Graham, below: