The network, which commemorates its 25th anniversary this year, will offer fans the chance to watch Married with Children's original 1987 pilot episode on Sunday, April 22 as part of its celebrations.
In addition, Fox will encore the 500th episode of popular animated series The Simpsons entitled 'Long Last Leave' on the same night.
Following the broadcasts, the channel will air a two-hour 25th Anniversary Special featuring clips from and tributes to some of its most groundbreaking and memorable series over the past several decades.
The programme will also feature reunions of the casts of several series, including Married with Children, In Living Colour and That '70s Show.
Fox's 25th anniversary programming airs April 22 beginning at 7/6c.
Earlier this week Simpsons creator Matt Groening finally revealed the location of the show's fictional Springfield.
> 'X-Files', 'Married with Children' stars to celebrate Fox 25th anniversary