Syfy axed Eureka in August, with producer Amy Berg blaming the decision on financial issues.
"I'd love to do a Eureka movie for Syfy," Ferguson, who plays Sheriff Jack Carter, told TV Guide.
"Our sets are gone but our characters could move to Chicago to handle an urgent problem. Only with us, it would probably be more like Bakersfield or Stockton."
Ferguson added that the cancellation of Eureka had come as "a surprise" to the show's cast and crew.
"We never had better ratings than we did last season and we're as strong as we've ever been, creatively speaking," he argued.
"[But] I was incredibly grateful we got the word [about the cancellation] three weeks before we stopped shooting. We all had a chance to say goodbye."
The actor also revealed that the final episode of Eureka does not have "a major sense of finality".
"It's by no means low-key or just another day at the office - big things happen," he insisted. "But it's not done in a cataclysmic, the world-is-gonna-end sort of way."
The series finale will be "pretty bittersweet" for long-term fans, Ferguson claimed.
"Our audience is already so sad that the show is going away," he said. "But nothing goes on forever. The best we can do is wrap it up in an honourable way."
Eureka airs on Mondays at 9/8c in the US. The final season will premiere on Syfy UK on Wednesday, May 16 at 9pm.
> Eureka exec: 'Final season is love letter to fans'
Watch a clip from the final season of Eureka below: