The USA Network series will return for a fourth season on Tuesday, July 10, it was recently announced.
Weston will appear in the episode 'Diminishing Returns' as criminal mastermind David Cook, according to The Hollywood Reporter.
An elusive crook, the character has been a target for special agent Peter Burke (Tim DeKay) since he joined the FBI.
Weston, who played private detective Lucas Douglas on House between 2008 and 2010, has also appeared on Law & Order: SVU and NCIS: Los Angeles.
Laurie Williams (Blue Bloods) will also star in 'Diminishing Returns' as gem trader Rina Oaks, Cook's fence for stolen jewellery.
White Collar will air on Tuesday nights at 9/8c when it returns to USA Network.
> Smallville star Laura Vandervoort lands White Collar role
Watch a trailer for White Collar season four below: