The second season of the E! series is currently airing in the US and the UK but will be the last, TMZ claims.
The couple have reportedly decided to end the show so that Odom can focus on his basketball career.
Odom recently moved from the LA Lakers to the Dallas Mavericks but moved on again earlier this month.
He is now said to be focused on his sporting career and so will no longer film Khloe & Lamar.
E! has allegedly tried to persuade the couple to shoot another season, but they are thought to have refused to do so.
However, they are expected to appear occasionally on Keeping Up with the Kardashians, which was recently renewed for three more seasons.