Jane by Design follows high school student Jane (Erica Dasher), who lands a fashion job as an assistant to creative director Gray Chandler Murray (Andie MacDowell) when she is mistaken for an adult.
The Desperate Housewives actress will portray Jane's long-lost mother for four episodes. She'll make her series debut on June 19.
Hatcher will also make her directorial debut in an upcoming episode of Jane by Design, which will return for its second season on June 5 at 9pm ET.
Hatcher wrapped the filming of Desperate Housewives' series finale last week. The show will air its final episode on Sunday, May 13 on ABC.
"I feel like [the series finale] does a pretty good job at honouring all the different characters and their sort of unique wheelhouses that they brought... to Desperate Housewives," Hatcher said.
Watch a clip of Teri Hatcher on Desperate Housewives below (US only):