The actor will play Bart Ganzel, the owner of an escort service, reports TV Line.
Ganzel becomes involved in a criminal investigation when one of his high-end call girls is murdered at a party.
47-year-old Jacobson has played Dr. Taub on Fox's House since 2007 and has also appeared in episodes of The Good Wife and Royal Pains.
Grey's Anatomy actress Brooke Smith will also appear in the SVU finale as Ganzel's business rival, while Eric Ladin (The Killing) will play the famous news anchor who hosts the the party.
Pippa Black (Neighbours) has also been cast in the episode - titled 'Rhodium Nights' - as a call girl.
Law & Order: SVU continues on Wednesdays at 10/9c on NBC. The season finale is scheduled to air on May 23.