The ABC series has already featured cameos from Dean Cain and Mad Men's Kiernan Shipka, but Van Der Beek revealed he's most keen to reunite with his Dawson's Creek co-star Williams.
"If we get to go for season two, [Michelle will] definitely be getting a phone call," Van Der Beek told TV Guide.
Williams recently revealed that she would love to reunite with Van Der Beek and her other Dawson's Creek castmates.
"I've always said, I'm totally up for reunion tours, reunion shows, so we can do that," Williams said earlier this month.
Williams and Van Der Beek starred on Dawson's Creek for six seasons from 1998 to 2003.
Don't Trust the B**** in Apartment 23 airs Wednesdays at 9.30/8.30c on ABC.
Watch a clip from Don't Trust the B**** in Apartment 23 below: