Deadline reports that the two latest pilot orders will join NBC's programming slate for the new season.
1600 Penn is set in the White House and stars Bill Pullman as President Dale Gilchrist, with Prom Night actress Brittany Snow playing his perfectionist daughter.
The show also features Jenna Elfman as the First Lady and Andre Holland (Friends with Benefits) as the White House press secretary.
Jon Lovett, a former speechwriter for current US president Barack Obama, is a co-writer and executive producer for 1600 Penn.
Animal Practice - formerly known as Animal Kingdom - stars Weeds actor Justin Kirk as George, a cantankerous vet who loves animals but dislikes their owners.
Amy Huberman (Threesome) was cast as Dorothy - George's ex-girlfriend - who runs the animal hospital where he works.
The new commissions follow reports that JJ Abrams and Eric Kripke's drama project Revolution, Ryan Murphy's comedy New Normal and Anne Heche's Save Me have all been ordered to series today.