Jimmy Kimmel Live will broadcast five original shows from October 29 to November 2.
The last time Kimmel, 44, took his show on the road was in 2006 to the historic GEM Theatre in Detroit, Michigan, but this marks the first time Jimmy Kimmel Live will travel to the East Coast.
The New York shows, which will occur at the same time as the Brooklyn Nets kick off their inaugural season, will be held at the Brooklyn Academy of Music.
Last month, Kimmel was the featured speaker at the White House Correspondents' Dinner, where he poked fun at President Barack Obama, New Jersey Governor Chris Christie and Republican presidential candidate Mitt Romney.
Kimmel is set to host the 64th annual Primetime Emmy Awards on September 23 on ABC.
Watch a clip of Jimmy Kimmel Live below: