The presenter explained that producing television for nearly two decades allowed him to seamlessly adjust to starring in his own series in 2009.
"[The transition] was relatively easy," Cohen told CNN. "I had been producing TV for 18 years before I went in front of the camera. So I had given enough direction to people that now I can take my own direction."
Cohen also offered a preview of his new book Most Talkative: Stories from the Front Lines of Pop Culture, which he said features quite a few embarrassing stories.
"I'm the butt of all my jokes. I think that it's more fun to talk about your failures than your successes because you can learn from your failures, and also you can laugh at them," he said.
Cohen recently disclosed on The Wendy Williams Show that he once kissed former 'N Sync member Lance Bass.
Watch What Happens Live airs Sundays through Thursdays at 11/10c on Bravo.