The Twilight director will helm an episode of the show's upcoming second season, reports Entertainment Weekly.
Set in the 1860s, Hell on Wheels tells the story of a former Confederate soldier (Anson Mount) who finds work on the first transcontinental railroad while trying to search for the Union soldiers who killed his family.
The AMC drama also stars Common, Colm Meaney, Dominique McElligott, Tom Noonan, Eddie Spears, Ben Esler and Phil Burke.
Next up for Hardwicke is Knockout and thriller Plush, which recently cast Emily Browning in the lead role.
Hell on Wheels will return for a second season on August 12 on AMC.
Watch the trailer for Hell on Wheels season one below: