The network is putting together a new version of the Wes Craven and Kevin Williamson horror franchise, according to TVLine.
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Executives Tony DiSanto (The Hills, Teen Wolf, Teen Mom) and Liz Gateley (The Hard Times of RJ Berger) will executive produce the project.
A search is currently being conducted to find a writer for the new project.
It is currently unknown if Craven and Williamson will have any involvement with the TV series.
The Scream franchise has brought in over $330 million at the global box office, with 2011's Scream 4 grossing $40 million in the US.
MTV has previously found success with Teen Wolf and Awkward among its scripted shows.
Craven has said that a fifth Scream movie is likely, while executive producer Harvey Weinstein has also lent his support for a new instalment.
Watch the trailer for Scream 4 below:
