The House creator will move from the show's producers Universal Television after eight years at the organisation. According to The Hollywood Reporter, the deal is in the eight-figure range.
Shore will develop his own new projects as part of the overall deal, and is also expected to collaborate with other writer-producers to help develop their ideas.
A former corporate lawyer, Shore broke into television as a writer on Due South during the 1990s, later working on shows such as Traders, Family Law, Law & Order and NYPD Blue.
Shore was honoured with the Emmy Award for 'Outstanding Writing' in 2005 for the House episode 'Three Stories'.
He recently said that the saddest part of the end of House for him would be no longer seeing the cast every day.