The Twilight star will voice a high school jock who becomes Meg's (voiced by Mila Kunis) crush on the animated show, reports Entertainment Weekly.
The pair apparently end up going on a date but it is revealed that Lutz's character is interested in a non-female member of the Griffin family.
Lutz will make his debut this fall when Family Guy comes back for its 11th season.
He was recently cast in the upcoming Tarzan movie, where he will play the title role.
Resident Evil actress Spencer Locke is in negotiations to portray Tarzan's female lead role Jane.
Watch a teaser trailer for Twilight: Breaking Dawn - Part 2 below: