McBride previously described the HBO comedy's third run as "the climax of the story".
"We always had imagined [the show] being something that's like a three-act structure," he told Digital Spy in April 2011. "The third act would obviously be the last act, so we're approaching it that way."
However, Eastbound & Down was recently picked up for a fourth season, with McBride confirming to HitFix that fans will get "a bonus round with Kenny Powers".
"In this day and age, whenever you have an opportunity to have creative freedom, to tell a story you want to tell, and to do it the way you want to do it, it seems like that's definitely a situation you don't want to take lightly," explained the star.
"With this show, it's always been something where, you know, we always just counted our blessings that we could make each season."
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McBride explained that season four will serve as "sort of an epilogue" to the first three runs of Eastbound & Down.
"For a while, we thought of this epilogue as something that was maybe like an hour-and-a-half special, and the more we talked about it, the more we thought it could be one more season," he revealed.
However, he concluded: "Kenny Powers isn't the sort of character where you can easily make 100 episodes and just keep it going forever. At some point, he becomes a caricature of himself and you lose the heart and the emotion of it."
Eastbound & Down is expected to return to HBO in the new year. In the UK, the series airs on FX.
Watch a trailer for the third season of Eastbound & Down below: